A conserved role of IQGAP1 in regulating TOR
نویسنده
چکیده
*Present address: Genentech Inc, 1 DNA way, South San Francisco, CA 94080, USA Present address: Stony Brook School of Dental Medicine 2013, Stony Brook, NY 11790, USA Present address: Warren Alpert Medical School, Division of Biology and Medicine, Department of Molecular Pharmacology, Physiology and Biotechnology, Brown University, 171 Meeting St, Box 389, Providence, RI 02912, USA Author for correspondence ([email protected]; [email protected])
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A conserved role of IQGAP1 in regulating TOR complex 1.
Defining the mechanisms that control cell growth and division is crucial to understanding cell homeostasis, which impacts human diseases such as cancer and diabetes. IQGAP1, a widely conserved effector and/or regulator of the GTPase CDC42, is a putative oncoprotein that controls cell proliferation; however, its mechanism in tumorigenesis is unknown. The mechanistic target of rapamycin (mTOR) pa...
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تاریخ انتشار 2012